Glycocalyx Research

Published Works by Dr. Hans Vink on the Glycocalyx

A Sampling of some of the over 250 articles authored/co-authored by Dr Vink.

Rovas A, Buscher K, Osiaevi I, Drost CC, Sackarnd J, Tepasse PR, Fobker M, Kühn J, Braune S, Göbel U, Thölking G, Gröschel A, Rossaint J, Vink H, Lukasz A, Pavenstädt H, Kümpers P.Angiogenesis. 2022 Nov;25(4):503-515.
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study.
an Haare J, Kooi ME, van Teeffelen JW, Vink H, Slenter J, Cobelens H, Strijkers GJ, Koehn D, Post MJ, van Bilsen M.Cardiovasc Diabetol. 2017 Apr 11;16(1):47
Metformin and sulodexide restore cardiac micro-vascular perfusion capacity in diet-induced obese rats.
van Lanen RH, Haeren RH, Staals J, Dings JT, Schijns OE, Hoogland G, van Kuijk SM, Kapsokalyvas D, van Zandvoort MA, Vink H, Rijkers K.J Cereb Blood Flow Metab. 2023 Oct;43(10):1737-1751
Cerebrovascular glycocalyx damage and microcirculation impairment in patients with temporal lobe epilepsy.
Fuchs A, Neumann T, Drinhaus H, Herrmann A, Vink H, Annecke T.J Clin Monit Comput. 2022 Apr;36(2):371-377.
Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study.
Hakvoort K, Otto L, Haeren R, Hoogland G, Schijns O, Vink H, Klein D, van Zandvoort M, Rijkers K.J Comp Neurol. 2021 Feb;529(3):605-615
Shedding light on human cerebral lipofuscin: An explorative study on identification and quantification.
Fuchs A, Groß S, Neumann T, Illerhaus A, Vink H, Klasen G, Gathof B, Annecke T.Blood Transfus. 2021 May;19(3):190-196
Immediate effects of whole blood donation on the endothelial surface layer and glycocalyx shedding.
van den Berg BM, Wang G, Boels MGS, Avramut MC, Jansen E, Sol WMPJ, Lebrin F, van Zonneveld AJ, de Koning EJP, Vink H, Gröne HJ, Carmeliet P, van der Vlag J, Rabelink TJ. J Am Soc Nephrol. 2019 Oct;30(10):1886-1897
Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium.
Rovas A, Sackarnd J, Rossaint J, Kampmeier S, Pavenstädt H, Vink H, Kümpers P. Crit Care. 2021 Mar 19;25(1):112
Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study.
Regier M, Drost CC, Rauen M, Pavenstädt H, Rovas A, Kümpers P, Vink H, Long RM, Linke WA, Nofer JR, Lukasz AH. Int J Mol Sci. 2022 Dec 8;23(24):15520
A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum.
Rovas A, Seidel LM, Vink H, Pohlkötter T, Pavenstädt H, Ertmer C, Hessler M, Kümpers P. Crit Care. 2019 Jul 24;23(1):260
Association of sublingual microcirculation para-meters and endothelial glycocalyx dimensions in resuscitated sepsis.
Jaarsma C, Vink H, van Haare J, Bekkers SCAM, van Rooijen BD, Backes WH, Wildberger JE, Crijns HJ, van Teeffelen J, Schalla S. Int J Cardiol. 2017 Dec 1;248:433-439
Non-invasive assessment of microvascular dysfunc-tion in patients with microvascular angina.
Yuan L, Cheng S, Sol WMPJ, van der Velden AIM, Vink H, Rabelink TJ, van den Berg BM. ERJ Open Res. 2022 May 3;8(2):00652-2021
Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit.
Vlahu CA, Lemkes BA, Struijk DG, Koopman MG, Krediet RT, Vink H.J Am Soc Nephrol. 2012 Nov;23(11)
Damage of the endothelial glycocalyx in dialysis patients.
van den Berg BM, Vink H, Spaan JA.Circ Res. 2003 Apr 4;92(6):592-4
The endothelial glycocalyx protects against myocardial edema.
Zhang CE, Staals J, van Oostenbrugge RJ, Vink H. Front Neurol. 2019 Dec 3;10:1268
Uncoupling of Microvascular Blood Flow and Capillary Density in Vascular Cognitive Impairment.
Martens RJ, Vink H, van Oostenbrugge RJ, Staals J. Cerebrovasc Dis. 2013;35(5):451-4.
Sublingual microvascular glycocalyx dimensions in lacunar stroke patients.
Weinbaum S, Zhang X, Han Y, Vink H, Cowin SC. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7988-95.
Mechanotransduction and flow across the endothelial glycocalyx.
Mulders TA, Nieuwdorp M, Stroes ES, Vink H, Pinto-Sietsma SJ. Int J Cardiol. 2013 Oct 12;168(5):5026-8.
Non-invasive assessment of microvascular dys-function in families with premature coronary artery disease.
Potter DR, van Teeffelen J, Vink H, van den Berg BM. Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H711-7.
Perturbed mechano-transduction by endothelial surface glycocalyx modification greatly impairs the arteriogenic process.
Snoeijs MG, Vink H, Voesten N, Christiaans MH, Daemen JW, Peppelenbosch AG, Tordoir JH, Peutz-Kootstra CJ, Buurman WA, Schurink GW, van Heurn LW. Am J Physiol Renal Physiol. 2010 Nov;299(5):F1134-40.
Acute ischemic injury to the renal microvasculature in human kidney transplan-tation.
Wijnands KA, Vink H, Briedé JJ, van Faassen EE, Lamers WH, Buurman WA, Poeze M. PLoS One. 2012;7(5):e37439.
Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia.
Machin DR, Gates PE, Vink H, Frech TM, Donato AJ. J Rheumatol. 2017 Nov;44(11):1603-1611.
Automated Measurement of Microvascular Function Reveals Dysfunction in Systemic Sclerosis: A Cross-sectional Study.
Dane MJ, Khairoun M, Lee DH, van den Berg BM, Eskens BJ, Boels MG, van Teeffelen JW, Rops AL, van der Vlag J, van Zonneveld AJ, Reinders ME, Vink H, Rabelink TJ. Clin J Am Soc Nephrol. 2014 Apr;9(4):698-704
Association of kidney function with changes in the endothelial surface layer.
Dane MJ, van den Berg BM, Avramut MC, Faas FG, van der Vlag J, Rops AL, Ravelli RB, Koster BJ, van Zonneveld AJ, Vink H, Rabelink TJ. Am J Pathol. 2013 May;182(5):1532-40.
Glomerular endothelial surface layer acts as a barrier against albumin filtration.
Meuwese MC, Mooij HL, Nieuwdorp M, van Lith B, Marck R, Vink H, Kastelein JJ, Stroes ES. J Lipid Res. 2009 Jan;50(1):148-53.
Partial recovery of the endothelial glycocalyx upon rosuvastatin therapy in patients with heterozygous familial hypercholesterolemia
Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet.van Haare J, Kooi ME, Vink H, Post MJ, van Teeffelen JW, Slenter J, Munts C, Cobelens H, Strijkers GJ, Koehn D, van Bilsen M. Cardiovasc Diabetol. 2015 Nov 17;14:150.
Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet.
Lee DH, Dane MJ, van den Berg BM, Boels MG, van Teeffelen JW, de Mutsert R, den Heijer M, Rosendaal FR, van der Vlag J, van Zonneveld AJ, Vink H, Rabelink TJ; NEO study group.PLoS One. 2014 May 9;9(5):e96477
Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion.
Van Teeffelen J, Vink H.J Appl Physiol (1985). 2008 Mar;104(3):895.
Capillary blood volume increase in already perfused capillaries: role for glycocalyx modulation.
Koning NJ, Vonk AB, Vink H, Boer C.Microcirculation. 2016 Jan;23(1):69-74
Side-by-Side Alterations in Glycocalyx Thickness and Perfused Microvascular Density During Acute Microcirculatory Alterations in Cardiac Surgery.
Lam PK, McBride A, Le DHT, Huynh TT, Vink H, Wills B, Yacoub S. Front Med (Lausanne). 2020 Oct 16;7:545813..
Visual and Biochemical Evidence of Glycocalyx Disruption in Human Dengue Infection, and Association With Plasma Leakage Severity.
Cornelis T, Broers NJ, Titulaer DC, Henskens YM, van Oerle R, van der Sande FM, Spronk HM, Vink H, Leunissen KM, ten Cate H, Kooman JP.Blood Purif. 2014;38(3-4):203-10.
Effects of ultrapure hemodialysis and low molecular weight heparin on the endothelial surface layer.
Rovas A, Lukasz AH, Vink H, Urban M, Sackarnd J, Pavenstädt H, Kümpers P.Scand J Trauma Resusc Emerg Med. 2018 Feb 14;26(1):16.
Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit - the GlycoNurse study.
Astapenko D, Pouska J, Benes J, Skulec R, Lehmann C, Vink H, Cerny V.Clin Hemorheol Microcirc. 2019;72(1):11-21.
Neuraxial anesthesia is less harmful to the endothelial glycocalyx during elective joint surgery compared to general anesthesia.
Nieuwdorp M, Mooij HL, Kroon J, Atasever B, Spaan JA, Ince C, Holleman F, Diamant M, Heine RJ, Hoekstra JB, Kastelein JJ, Stroes ES, Vink H.Diabetes. 2006 Apr;55(4):1127-32.
Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes.
Eskens BJ, Zuurbier CJ, van Haare J, Vink H, van Teeffelen JW. Cardiovasc Diabetol. 2013 Dec 5;12:175.
Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice.
Gouverneur M, Spaan JA, Pannekoek H, Fontijn RD, Vink H. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H458-2.
Fluid shear stress stimulates incorporation of hyaluronan into endothelial cell glycocalyx
Pacella JJ, Kameneva MV, Brands J, Lipowsky HH, Vink H, Lavery LL, Villanueva FS. Microcirculation. 2012 Oct;19(7):580-5.
Modulation of pre-capillary arteriolar pressure with drag-reducing polymers: a novel method for enhancing microvascular perfusion.
Constantinescu AA, Vink H, Spaan JA.Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1541-7.
Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface.
Eskens BJ, Leurgans TM, Vink H, Vanteeffelen JW. Physiol Rep. 2014 Jan 6;2(1):e00194.
Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet-induced obesity in mice
Brands J, Vink H, Van Teeffelen JW.Med Biol Eng Comput. 2011 Dec;49(12):1471-9.
Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation
rands J, van Haare J, Vink H, Vanteeffelen JW. Physiol Rep. 2013 Oct;1(5):e00102.
Whole-body recruitment of glycocalyx volume during intravenous adenosine infusion
Groen BB, Hamer HM, Snijders T, van Kranenburg J, Frijns D, Vink H, van Loon LJ. J Appl Physiol (1985). 2014 Apr 15;116(8):998-1005
Skeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes
Nieuwdorp M, Meuwese MC, Mooij HL, Ince C, Broekhuizen LN, Kastelein JJ, Stroes ES, Vink H. J Appl Physiol (1985). 2008 Mar;104(3):845-52.
Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability
Rovas A, Lukasz AH, Vink H, Urban M, Sackarnd J, Pavenstädt H, Kümpers P.Scand J Trauma Resusc Emerg Med. 2018 Feb 14;26(1):16.
Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit - the GlycoNurse study.
Eskens BJ, Zuurbier CJ, van Haare J, Vink H, van Teeffelen JW. Cardiovasc Diabetol. 2013 Dec 5;12:175.
Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice
Heparin impairs glycocalyx barrier properties and attenuates shear dependent vasodilation in mice.VanTeeffelen JW, Brands J, Jansen C, Spaan JA, Vink H. Hypertension. 2007 Jul;50(1):261-7.
Heparin impairs glycocalyx barrier properties and attenuates shear dependent vasodilation in mice.
Nieuwdorp M, Mooij HL, Kroon J, Atasever B, Spaan JA, Ince C, Holleman F, Diamant M, Heine RJ, Hoekstra JB, Kastelein JJ, Stroes ES, Vink H.Diabetes. 2006 Apr;55(4):1127-32.
Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes.
Koning NJ, Vonk AB, Vink H, Boer C.Microcirculation. 2016 Jan;23(1):69-74.
Side-by-Side Alterations in Glycocalyx Thickness and Perfused Microvascular Density During Acute Microcirculatory Alterations in Cardiac Surgery.

rands J, van Haare J, Vink H, Vanteeffelen JW. Physiol Rep. 2013 Oct;1(5):e00102.
Whole-body recruitment of glycocalyx volume during intravenous adenosine infusion
Brands J, Vink H, Van Teeffelen JW.Med Biol Eng Comput. 2011 Dec;49(12):1471-9.
Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation
Pflugers Arch. 2009 Apr;457(6):1199-206.
Impaired glycocalyx barrier properties contribute to enhanced intimal low-density lipoprotein accumulation at the carotid artery bifurcation in mice
Nijenhuis N, Mizuno D, Schmidt CF, Vink H, Spaan JA.Biomacromolecules. 2008 Sep;9(9):2390-8.
Microrheology of hyaluronan solutions: implications for the endothelial glycocalyx
VanTeeffelen JW, Constantinescu AA, Vink H, Spaan JA. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H447-54.
Hypercholesterolemia impairs reactive hyperemic vasodilation of 2A but not 3A arterioles in mouse cremaster muscle
Nieuwdorp M, van Haeften TW, Gouverneur MC, Mooij HL, van Lieshout MH, Levi M, Meijers JC, Holleman F, Hoekstra JB, Vink H, Kastelein JJ, Stroes ES. Diabetes. 2006 Feb;55(2):480-6.
Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo
van den Berg BM, Spaan JA, Rolf TM, Vink H. Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H915-20.
Atherogenic region and diet diminish glycocalyx dimension and increase intima-to-media ratios at murine carotid artery bifurcation
Grundmann S, Schirmer SH, Hekking LH, Post JA, Ionita MG, de Groot D, van Royen N, van den Berg B, Vink H, Moser M, Bode C, de Kleijn D, Pasterkamp G, Piek JJ, Hoefer IE. J Cell Mol Med. 2009 Sep;13(9B):3463-74.
Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis
Bastiaanse J, Slaaf DW, oude Egbrink MG, Anderson GL, Vink H, van der Heijden BE, Kon M. Clin Sci (Lond). 2005 Jul;109(1):117-23.
Effect of hypothermia and HTK on the microcirculation in the rat cremaster muscle after ischaemia
van Haaren PM, VanBavel E, Vink H, Spaan JA. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2848-56.
Localization of the permeability barrier to solutes in isolated arteries by confocal microscopy
VanTeeffelen JW, Brands J, Janssen BJ, Vink H. J Appl Physiol (1985). 2013 May;114(9):1132-40.
Effect of acute hyaluroni-dase treatment of the glycocalyx on tracer-based whole body vascular volume estimates in mice
Broekhuizen LN, van Wijk DF, Vink H, Stalmach A, Crozier A, Hutten BA, Kastelein JJ, Hugenholtz PG, Koenig W, Stroes ES. Br J Nutr. 2011 Nov;106(9):1416-22
Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors
Zuurbier CJ, Demirci C, Koeman A, Vink H, Ince C. J Appl Physiol (1985). 2005 Oct;99(4):1471-6.
Short-term hyperglycemia increases endothelial glycocalyx permeability and acutely decreases lineal density of capillaries with flowing red blood cells
Brands J, Spaan JA, Van den Berg BM, Vink H, VanTeeffelen JW. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H515-23.
Acute attenuation of glycocalyx barrier properties increases coronary blood volume independently of coronary flow reserve
Donati A, Damiani E, Luchetti M, Domizi R, Scorcella C, Carsetti A, Gabbanelli V, Carletti P, Bencivenga R, Vink H, Adrario E, Piagnerelli M, Gabrielli A, Pelaia P, Ince C. Crit Care. 2014 Feb 17;18(1):R33.
Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study
VanTeeffelen JW, Constantinescu AA, Brands J, Spaan JA, Vink H.J Physiol. 2008 Jul 1;586(13):3207-18.
Bradykinin- and sodium nitroprusside-induced increases in capillary tube haematocrit in mouse cremaster muscle are associated with impaired glycocalyx barrier properties
skens BJ, Mooij HL, Cleutjens JP, Roos JM, Cobelens JE, Vink H, Vanteeffelen JW.PLoS One. 2013;8(1):e55399.
Rapid insulin-mediated increase in microvascular glycocalyx accessibility in skeletal muscle may contribute to insulin-mediated glucose disposal in rats
VanTeeffelen JW, Dekker S, Fokkema DS, Siebes M, Vink H, Spaan JA.Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2508-13.
Hyaluronidase treatment of coronary glycocalyx increases reactive hyperemia but not adenosine hyperemia in dog hearts
van Haaren PM, VanBavel E, Vink H, Spaan JA. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2503-7
Charge modification of the endothelial surface layer modulates the permeability barrier of isolated rat mesenteric small arteries

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