Research & Studies

GlycoCheck is being used by researchers in hospitals and universities in Africa, Asia, Australia, China, Europe, Japan, Russia, and the United States.

Examples of Diseases and Conditions Being Researched

    • Type 2 Diabetes
    • Stroke
    • Early Cognition Impairment
    • Epilepsy
    • Syndrome X
    • Kidney failure / Hemodialysis
    • Pre-eclampsia / HELLP
    • Sepsis / Septic Shock
    • Pre-Eclampsia
    • Atherosclerosis
    • Heart failure
    • Premature Atherosclerosis
    • Malaria / Dengue
    • Obesity
    • ESRD Proteinuria
    • Inflammation

Most Recent Published Papers Using GlycoCheck

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  • Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study

    Effects of a single aerobic exercise on perfuse...

    Abstract The endothelium and the glycocalyx play a pivotal role in regulating microvascular function and perfusion in health and critical illness. It is unknown today, whether aerobic exercise immediately affects...

    Effects of a single aerobic exercise on perfuse...

    Abstract The endothelium and the glycocalyx play a pivotal role in regulating microvascular function and perfusion in health and critical illness. It is unknown today, whether aerobic exercise immediately affects...

  • Association of COVID-19 with impaired endothelial glycocalyx, vascular function and myocardial deformation four months after infection

    Association of COVID-19 with impaired endotheli...

    Abstract Aims SARS-CoV-2 infection may lead to endothelial and vascular dysfunction. We investigated alterations of arterial stiffness, endothelial coronary and myocardial function markers 4 months after COVID-19 infection. Methods and...

    Association of COVID-19 with impaired endotheli...

    Abstract Aims SARS-CoV-2 infection may lead to endothelial and vascular dysfunction. We investigated alterations of arterial stiffness, endothelial coronary and myocardial function markers 4 months after COVID-19 infection. Methods and...

  • Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines

    Managing sepsis and septic shock in an endothel...

      Abstract Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed...

    Managing sepsis and septic shock in an endothel...

      Abstract Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed...

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Key Partner in THE CRUCIAL CONSORTIUM

The Crucial Consortium brings together 12 partners from multiple fields (clinicians, fundamental scientists, scientific SMEs, exploitation and dissemination SME, management SME, and a patient advocacy), representing 7 different countries.

The Crucial Consortium aims to address a difficult problem regarding how co-morbidities give rise both to mental disorders and non-mental disorders. In order to achieve this, they have assembled a consortium that has a balanced mix of skills on several levels.

It consists of fundamental scientists and clinicians. It consists of specialists in neuroscience (UM, Scannexus) and in cardiovascular science (UCL, UNAV, FIMA, GlycoCheck, KU Leuven, VIB).

The clinical scientists are strong leaders in the field of MRI (UCL, UM, UNAV, Scannexus), whereas the fundamental partners have strong skills in molecular biology and genetics that will allow them to develop new biomarkers and identify new pathways for pharmaceutical targeting (FIMA, KU Leuven, VIB). Beyond bridging fundamental research and clinical applications, the project also combines several state-of-the-art technical approaches to answer the research objective. This includes cell signalling, (single cell) RNA-Seq, metabolic assessments, microvesicle’s biomarker identification, GlycoCheck measurements, and advanced imaging (MRI, 2-photon and light sheet microscopy). Read more here.

The Crucial Consortium has announced that they are launching a new study titled “Evaluation of microvascular rarefaction in vascular Cognitive Impairment and heart faiLure (CRUCIAL): Study protocol for an observational study.” The abstract can be viewed by clicking the name of the study.

Key Partner with INTERREG and HEALTHY AGING

Healthy Agingis a Euregional project within the Interreg Euregio Maas-Rhine program . The partners (BIOMED is the lead partner) within this consortium ( BIOMED , MUMC + , GIGA Liège , UKA , Curador , MyHealth , Imomec , GlycoCheck , Astel Medica and DNAmito) use their expertise and knowledge to the maximum to detect premature aging of the immune system and to slow down aging and related chronic conditions. This consortium wants to develop cross-border knowledge platforms within the EMR for sharing and disseminating knowledge. Most of the activities in this project have a very specific medical-scientific focus. The partners of this project aim to innovate and validate the knowledge collected in the context of these activities. The results of this project should lead to lower healthcare costs. This project is supported by the European Regional Development Fund of the European Union which, through cross-border projects, provides innovation, stimulates a healthy environment and the labor market. More information can be foundhere.INTERREG Program and financing partners include:

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Universities & Hospitals Researching the Glycocalyx

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Reproducibility and Validity Studies

Clinical Papers

Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit – the GlycoNurse study
Kuempers 2018: good intra-observer and excellent intra-class reproducibility of PBR measurements in ICU and ER patients; increased PBR in ICU patients compared with ER patients. PBR correlates with Mean Arterial Pressure (MAP) and with CRP and SOFA scores.

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion


Weissgerber 2019: reproducibility of PBR measurements in pre-eclampsia patients increases when taking average of 2 or 3 measurements.

Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis


Kuempers 2019: PBR in patients correlates with plasma Syndecan-1 levels and with Atomic Force Microscope measurements of glycocalyx dimension on cultured endothelial cells exposed to patients' plasma.

Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall


Gorshkov 2018: Increase of PBR is associated with ischemic heart disease.

Experimental Papers

Rapid Insulin-Mediated Increase in Microvascular Glycocalyx Accessibility in Skeletal Muscle May Contribute to Insulin-Mediated Glucose Disposal in Rats


Eskens 2013: Insulin increases PBR, and hyaluronidase treatment of the glycocalyx abolishes the insulin effect

Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet-induced obesity in mice


Eskens 2014: PBR is increased in response to a High Fat Diet (figure 2D) and PBR correlates with increased duration and level of plasma glucose (area under the curve of glucose) after Glucose Tolerance Test.

Perturbed mechanotransduction by endothelial surface glycocalyx modification greatly impairs the arteriogenic process


Potter 2015: Inhibition of endothelial hyaluronan production increases PBR, which is associated with diminished glycocalyx dimension as measured with the Dextran 150kDa exclusion zone (figure 1).

Advanced age results in a diminished endothelial glycocalyx


Machin 2018: PBR increase in old mice is associated with decreased glycocalyx dimension, and increased PBR is associated with decreased glycocalyx dimension.

Researchers, physicians and healthcare practitionerscan schedule an online demonstration by contacting us.

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