27 results for “diabetes glycocalyx”
Peer-reviewed papers on the endothelial glycocalyx and microvascular health, Knowledge Base articles and news, ranked by relevance. Every paper links to the journal.
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Impact of dietary supplementation of glycocalyx precursors on vascular function in type 2 diabetes
Abstract Degradation of the endothelial glycocalyx in type 2 diabetes (T2D) is thought to contribute to impaired shear stress mechanotransduction, leading to endothelial dysfunction and the development of cardiovascular disease....
BlogImpact of dietary supplementation of glycocalyx precursors on vascular function in type 2 diabetes
Abstract Degradation of the endothelial glycocalyx in type 2 diabetes (T2D) is thought to contribute to impaired shear stress mechanotransduction, leading to endothelial dysfunction and the development of cardiovascular disease....
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Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus
Abstract Aims/hypothesis: Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus,...
BlogEffect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus
Abstract Aims/hypothesis: Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus,...
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Dietary Interventions on Glycocalyx Dimensions in South Asian Patients With Diabetic Nephropathy (Glycotreat)
This study valuates the effect of a fasting mimicking diet and a food supplement on the microvascular health and urinary heparanase levels in South Asian type 2 diabetic patients...
BlogDietary Interventions on Glycocalyx Dimensions in South Asian Patients With Diabetic Nephropathy (Glycotreat)
This study valuates the effect of a fasting mimicking diet and a food supplement on the microvascular health and urinary heparanase levels in South Asian type 2 diabetic patients...
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Early detection of left ventricular dysfunction in first-degree relatives of diabetic patients by myocardial deformation imaging: The role of endothelial glycocalyx damage
Abstract Background: First-degree relatives of type-2 diabetes patients (FDR) present insulin resistance. We investigated whether FDR and dysglycaemic subjects demonstrate abnormal endothelial glycocalyx and LV deformation during postprandial hyperglycemia. Methods: We studied...
BlogEarly detection of left ventricular dysfunction in first-degree relatives of diabetic patients by myocardial deformation imaging: The role of endothelial glycocalyx damage
Abstract Background: First-degree relatives of type-2 diabetes patients (FDR) present insulin resistance. We investigated whether FDR and dysglycaemic subjects demonstrate abnormal endothelial glycocalyx and LV deformation during postprandial hyperglycemia. Methods: We studied...
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Effects of Glucagon Like Peptide 1 Receptor Agonists, Sodium Glucose Cotransporter 2 Inhibitors, and Their Combination on Endothelial Glycocalyx, Arterial Function, and Myocardial Work Index in Patients With Type 2 Diabetes Mellitus After 12 Month Treatme
Abstract Background We investigated the effects of insulin, glucagon‐like peptide‐1 receptor agonists (GLP‐1RA), sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i), and their combination on vascular and cardiac function of patients with type 2...
BlogEffects of Glucagon Like Peptide 1 Receptor Agonists, Sodium Glucose Cotransporter 2 Inhibitors, and Their Combination on Endothelial Glycocalyx, Arterial Function, and Myocardial Work Index in Patients With Type 2 Diabetes Mellitus After 12 Month Treatme
Abstract Background We investigated the effects of insulin, glucagon‐like peptide‐1 receptor agonists (GLP‐1RA), sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i), and their combination on vascular and cardiac function of patients with type 2...
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Sublingual endothelial glycocalyx and atherosclerosis. A cross-sectional study
Abstract Background: Damage to endothelial glycocalyx is thought to be an early marker of atherosclerosis and measuring reduced glycocalyx size clinically via the Perfused Boundary Region (PBR) may allow early detection...
BlogSublingual endothelial glycocalyx and atherosclerosis. A cross-sectional study
Abstract Background: Damage to endothelial glycocalyx is thought to be an early marker of atherosclerosis and measuring reduced glycocalyx size clinically via the Perfused Boundary Region (PBR) may allow early detection...
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Differential effects of heat-not-burn, electronic, and conventional cigarettes on endothelial glycocalyx
Introduction Heat-not-burn cigarettes (HNBC) and electronic cigarette (Ecig) constitute non-combustible smoking products. Studies report detrimental acute effects on cardiovascular function after use of these novel smoking products.1,2 However, the amount of...
BlogDifferential effects of heat-not-burn, electronic, and conventional cigarettes on endothelial glycocalyx
Introduction Heat-not-burn cigarettes (HNBC) and electronic cigarette (Ecig) constitute non-combustible smoking products. Studies report detrimental acute effects on cardiovascular function after use of these novel smoking products.1,2 However, the amount of...
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Vascular Endothelial Glycocalyx Damage in COVID-19
Abstract and Figures The new coronavirus disease-2019 (COVID-19), which is spreading around the world and threatening people, is easily infecting a large number of people through airborne droplets; moreover, patients...
BlogVascular Endothelial Glycocalyx Damage in COVID-19
Abstract and Figures The new coronavirus disease-2019 (COVID-19), which is spreading around the world and threatening people, is easily infecting a large number of people through airborne droplets; moreover, patients...
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Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion
Abstract Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a pregnancy-specific hypertensive disorder characterized by endothelial...
BlogEarly Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion
Abstract Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a pregnancy-specific hypertensive disorder characterized by endothelial...
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The role of the endothelial glycocalyx in fibrotic interstitial lung disease
Abstract Background and Aims The interstitial lung diseases are a heterogenous group of conditions with varying degrees of inflammation and fibrosis of the lungs. Disruption of the endothelial glycocalyx (EG) and...
BlogThe role of the endothelial glycocalyx in fibrotic interstitial lung disease
Abstract Background and Aims The interstitial lung diseases are a heterogenous group of conditions with varying degrees of inflammation and fibrosis of the lungs. Disruption of the endothelial glycocalyx (EG) and...
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Associations Between Adipose Tissue Glycocalyx Quality, Nox Activity, and Microvascular Blood Flow
Introduction In the United States, cardiovascular disease (CVD) is recognized as the number one cause of death for the general population (He et al., 2021). In 2017, CVD comprised 23%...
BlogAssociations Between Adipose Tissue Glycocalyx Quality, Nox Activity, and Microvascular Blood Flow
Introduction In the United States, cardiovascular disease (CVD) is recognized as the number one cause of death for the general population (He et al., 2021). In 2017, CVD comprised 23%...
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Endothelial Glycocalyx Integrity in Treatment-Naïve People Living with HIV before and One Year after Antiretroviral Treatment Initiation
Abstract Endothelial glycocalyx (EG) derangement has been associated with cardiovascular disease (CVD). Studies on EG integrity among people living with HIV (PLWH), are lacking. We conducted a prospective cohort study...
BlogEndothelial Glycocalyx Integrity in Treatment-Naïve People Living with HIV before and One Year after Antiretroviral Treatment Initiation
Abstract Endothelial glycocalyx (EG) derangement has been associated with cardiovascular disease (CVD). Studies on EG integrity among people living with HIV (PLWH), are lacking. We conducted a prospective cohort study...
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Impaired Endothelial Glycocalyx Predicts Adverse Outcome in Subjects Without Overt Cardiovascular Disease: a 6-Year Follow-up Study
Abstract We investigated whether disturbance of glycocalyx integrity is related with increased cardiovascular risk. In 600 healthy subjects, we measured perfused boundary region (PBR), a marker of glycocalyx integrity, in...
BlogImpaired Endothelial Glycocalyx Predicts Adverse Outcome in Subjects Without Overt Cardiovascular Disease: a 6-Year Follow-up Study
Abstract We investigated whether disturbance of glycocalyx integrity is related with increased cardiovascular risk. In 600 healthy subjects, we measured perfused boundary region (PBR), a marker of glycocalyx integrity, in...
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Endothelial glycocalyx integrity in oncological patients
Abstract Background Cancer is associated with early changes in the cardiovascular system (CV) before overt cardiotoxicity. Endothelial dysfunction is induced by chemotherapeutic regimens but there is no data for endothelial...
BlogEndothelial glycocalyx integrity in oncological patients
Abstract Background Cancer is associated with early changes in the cardiovascular system (CV) before overt cardiotoxicity. Endothelial dysfunction is induced by chemotherapeutic regimens but there is no data for endothelial...
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How to Repair Your Glycocalyx: Measure, Restore, Verify
Yes, the glycocalyx can be repaired — and measured. A repeatable, evidence-based way to see, rebuild and prove the health of your microcirculation: measure your glycocalyx with a GlycoCheck test,...
BlogHow to Repair Your Glycocalyx: Measure, Restore, Verify
Yes, the glycocalyx can be repaired — and measured. A repeatable, evidence-based way to see, rebuild and prove the health of your microcirculation: measure your glycocalyx with a GlycoCheck test,...
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Effects of Different Antidiabetic Medications on Endothelial Glycocalyx, Myocardial Function, and Vascular Function in Type 2 Diabetic Patients: One Year Follow-Up Study
Abstract Background: Poor glycaemic control affects myocardial function. We investigated changes in endothelial function and left ventricular (LV) myocardial deformation in poorly controlled type 2 diabetics before and after glycaemic control...
BlogEffects of Different Antidiabetic Medications on Endothelial Glycocalyx, Myocardial Function, and Vascular Function in Type 2 Diabetic Patients: One Year Follow-Up Study
Abstract Background: Poor glycaemic control affects myocardial function. We investigated changes in endothelial function and left ventricular (LV) myocardial deformation in poorly controlled type 2 diabetics before and after glycaemic control...
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Are Underlying Conditions Linked to COVID-19 Mortality Rates as a Result of Poor Glycocalyx Health?
Discovery Breakthrough Opportunities Underlying chronic conditions can be deadly for people with COVID-19. Answers are needed now. So it’s vital to find solutions quickly, and we’d like to remind...
BlogAre Underlying Conditions Linked to COVID-19 Mortality Rates as a Result of Poor Glycocalyx Health?
Discovery Breakthrough Opportunities Underlying chronic conditions can be deadly for people with COVID-19. Answers are needed now. So it’s vital to find solutions quickly, and we’d like to remind...
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Skeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes
Abstract Adequate muscle perfusion is required for the maintenance of skeletal muscle mass. Impairments in microvascular structure and/or function with aging and type 2 diabetes have been associated with the...
BlogSkeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes
Abstract Adequate muscle perfusion is required for the maintenance of skeletal muscle mass. Impairments in microvascular structure and/or function with aging and type 2 diabetes have been associated with the...
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Association of Gestational Diabetes With Subclinical Cardiovascular Disease on Echocardiogram and Endothelial Function Testing (Abstract 12986)
Abstract Introduction: Gestational diabetes mellitus (GDM) increases risk for cardiovascular disease (CVD). The subclinical cardiovascular structural and functional changes that contribute to long-term cardiovascular risk are unclear. Hypothesis: We hypothesized that GDM...
BlogAssociation of Gestational Diabetes With Subclinical Cardiovascular Disease on Echocardiogram and Endothelial Function Testing (Abstract 12986)
Abstract Introduction: Gestational diabetes mellitus (GDM) increases risk for cardiovascular disease (CVD). The subclinical cardiovascular structural and functional changes that contribute to long-term cardiovascular risk are unclear. Hypothesis: We hypothesized that GDM...
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Role of dietary interventions on microvascular health in South-Asian Surinamese people with type 2 diabetes in the Netherlands; a randomized controlled trial
BACKGROUND/OBJECTIVES: We investigated whether dietary interventions, i.e. a fasting mimicking diet (FMD, Prolon®) or glycocalyx mimetic supplementation (EndocalyxTM) could stabilize microvascular function in Surinamese South-Asian patients with type 2 diabetes (SA-T2DM)...
BlogRole of dietary interventions on microvascular health in South-Asian Surinamese people with type 2 diabetes in the Netherlands; a randomized controlled trial
BACKGROUND/OBJECTIVES: We investigated whether dietary interventions, i.e. a fasting mimicking diet (FMD, Prolon®) or glycocalyx mimetic supplementation (EndocalyxTM) could stabilize microvascular function in Surinamese South-Asian patients with type 2 diabetes (SA-T2DM)...
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Endothelial dysfunction due to decreased nitric oxide bioavailability in dysglycaemic subjects and first-degree relatives of type 2 diabetic patients
Abstract Background/Introduction Oxidative stress plays an important role in the pathogenesis of type 2 diabetes mellitus. Purpose We aimed to investigate oxidative stress and nitrites/nitrates concentrations at baseline and during...
BlogEndothelial dysfunction due to decreased nitric oxide bioavailability in dysglycaemic subjects and first-degree relatives of type 2 diabetic patients
Abstract Background/Introduction Oxidative stress plays an important role in the pathogenesis of type 2 diabetes mellitus. Purpose We aimed to investigate oxidative stress and nitrites/nitrates concentrations at baseline and during...
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GLP-1s and Your Circulation: What the Scale Misses
GLP-1 medicines are good for your blood vessels: in a randomized trial they improved glycocalyx thickness more than insulin at a similar HbA1c — a pleiotropic effect worth paying attention...
BlogGLP-1s and Your Circulation: What the Scale Misses
GLP-1 medicines are good for your blood vessels: in a randomized trial they improved glycocalyx thickness more than insulin at a similar HbA1c — a pleiotropic effect worth paying attention...
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Endocalyx Pro Studies
Endocalyx Pro, which healthcare practitioners recommend to patients for optimum microvascular health, continues to be studied by researchers for its impacts on multiple conditions and diseases. Endocalyx Pro has completed,...
BlogEndocalyx Pro Studies
Endocalyx Pro, which healthcare practitioners recommend to patients for optimum microvascular health, continues to be studied by researchers for its impacts on multiple conditions and diseases. Endocalyx Pro has completed,...
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New Cardiovascular Disease Published Studies
Two new peer-reviewed research papers on cardiovascular disease have been published using GlycoCheck. Cardiovascular Disease study: a 6-Year Follow-up Impaired Endothelial Glycocalyx Predicts Adverse Outcome in Subjects Without Overt Cardiovascular...
BlogNew Cardiovascular Disease Published Studies
Two new peer-reviewed research papers on cardiovascular disease have been published using GlycoCheck. Cardiovascular Disease study: a 6-Year Follow-up Impaired Endothelial Glycocalyx Predicts Adverse Outcome in Subjects Without Overt Cardiovascular...
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