What is GlycoCalyx? Check Your GlycoCalyx With GlycoCheck and Repair with ReVasca

Learn everything you need to know about What is GlycoCalyx? Check Your GlycoCalyx With GlycoCheck and Repair with ReVasca in this comprehensive guide from GlycoCalyx.

Damage of the endothelial glycocalyx in dialysis patients

Abstract Damage to the endothelial glycocalyx, which helps maintain vascular homeostasis, heightens the sensitivity of the vasculature to atherogenic stimuli. Patients with renal failure have endothelial dysfunction and increased risk...

Erythrocyte Glycocalyx Reports Glomerular Endothelial Glycocalyx Damage in Disease and Predicts Glomerular Albumin Permeability

  Citation: Journal of the American Society of Nephrology  View Link  

The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine

Abstract The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the...

Is the systemic microvascular endothelial glycocalyx in peritoneal dialysis patients related to peritoneal transport?

Abstract Background/aims: The capillary wall coated by the endothelial glycocalyx is the main transport barrier during peritoneal dialysis (PD). Here, we investigated the relationships between measurements of the systemic endothelial glycocalyx...

How to Repair Your Glycocalyx: Measure, Restore, Verify

Yes, the glycocalyx can be repaired — and measured. A repeatable, evidence-based way to see, rebuild and prove the health of your microcirculation: measure your glycocalyx with a GlycoCheck test,...

Why Focusing Only on the Heart Misses the Mark: The Missing Link in Circulatory and Cardiovascular Health Revealed by GlycoCalyx

Learn everything you need to know about Why Focusing Only on the Heart Misses the Mark: The Missing Link in Circulatory and Cardiovascular Health Revealed by GlycoCalyx in this comprehensive...

Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier

Abstract In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in...

Endothelial and Glycocalyx Biomarkers in Children With Sepsis After One Bolus of Unbalanced or Balanced Crystalloids

Abstract Objectives:  To assess the disruption of endothelial glycocalyx integrity in children with sepsis receiving fluid resuscitation with either balanced or unbalanced crystalloids. The primary outcome was endothelial glycocalyx disruption...

Are Underlying Conditions Linked to COVID-19 Mortality Rates as a Result of Poor Glycocalyx Health?

  Discovery Breakthrough Opportunities Underlying chronic conditions can be deadly for people with COVID-19. Answers are needed now. So it’s vital to find solutions quickly, and we’d like to remind...

Acute ischemic injury to the renal microvasculature in human kidney transplantation

Abstract Increased understanding of the pathophysiology of ischemic acute kidney injury in renal transplantation may lead to novel therapies that improve early graft function. Therefore, we studied the renal microcirculation...

Ways and Means of Cellular Reconditioning for Kidney Regeneration

Abstract Background: Mitochondrial, lysosomal, and peroxisomal dysfunction; defective autophagy; mitophagy; and pexophagy, as well as the loss of glycocalyx integrity are known contributors to initiation and progression of diverse kidney diseases....

A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum

Abstract (1) Damage to the endothelial glycocalyx (eGC), a protective layer lining the endothelial luminal surface, is associated with chronic kidney disease (CKD), which leads to a worsening of cardiovascular...

Extracellular overhydration linked with endothelial dysfunction in the context of inflammation in haemodialysis dependent chronic kidney disease

Abstract Background: Haemodialysis (HD) patients are predisposed to dysregulated fluid balance leading to extracellular water (ECW) expansion. Fluid overload has been closely linked with outcome in these patients. This has mainly...

Association of kidney function with changes in the endothelial surface layer

Abstract Background and objectives: ESRD is accompanied by endothelial dysfunction. Because the endothelial glycocalyx (endothelial surface layer) governs interactions between flowing blood and the vessel wall, perturbation could influence disease progression....

The Measurement of the Endothelial Glycocalyx as a New Biomarker of Endothelial Derangement in Systemic Sclerosis: A Challenge for the Future

GLP-1s and Your Circulation: What the Scale Misses

GLP-1 medicines are good for your blood vessels: in a randomized trial they improved glycocalyx thickness more than insulin at a similar HbA1c — a pleiotropic effect worth paying attention...

Endocalyx Pro Studies

Endocalyx Pro, which healthcare practitioners recommend to patients for optimum microvascular health, continues to be studied by researchers for its impacts on multiple conditions and diseases. Endocalyx Pro has completed,...

Microvascular Dysfunction in COVID-19 Patients: MYSTIC Study

Research reveals that COVID-19 patients have severe damage to microcirculation and the endothelial glycocalyx. The data in a newly released study clearly show severe reduction of microcirculation and the endothelial...

Perfused boundary region as biomarker for endothelial integrity in former preterms in adolescence

Abstract Introduction Extremely low birth weight (ELBW) survivors have microvascular structural differences already described in kidney and retina, suggesting changes in endothelial integrity. A biomarker of endothelial integrity is perfused...

Role of dietary interventions on microvascular health in South-Asian Surinamese people with type 2 diabetes in the Netherlands; a randomized controlled trial

BACKGROUND/OBJECTIVES: We investigated whether dietary interventions, i.e. a fasting mimicking diet (FMD, Prolon®) or glycocalyx mimetic supplementation (EndocalyxTM) could stabilize microvascular function in Surinamese South-Asian patients with type 2 diabetes (SA-T2DM)...

Sublingual functional capillary rarefaction in chronic heart failure

Abstract Background and objective: Microcirculatory changes contribute to clinical symptoms and disease progression in chronic heart failure (CHF). A depression of coronary flow reserve is associated with a lower myocardial capillary...

Inflammatory and Angiogenic Factors Linked to Longitudinal Microvascular Changes in Hemodialysis Patients Irrespective of Treatment Dose Intensity

Abstract Background: Cardiovascular disease is a major contributor to the poor outcomes observed in hemodialysis. We investigated the relationship between hemodialysis intensity and vascular parameters in high-dose (HDHD; >12hrs/week) and Conventional...