Pregnancy & neonatal: 3 papers
Peer-reviewed work on the endothelial glycocalyx, microvascular health and the ingredients in our formulas, newest first. Abstracts are indexed here and every paper links to the journal.
-
Published paper
Association of Gestational Diabetes With Subclinical Cardiovascular Disease on Echocardiogram and Endothelial Function Testing (Abstract 12986)
This conference abstract reports a cross-sectional analysis of 217 women assessed roughly nine years after pregnancy, 53 of whom had a history of gestational diabetes. Women with prior gestational diabetes showed greater left ventricular wall thickness, worse diastolic function, and worse endothelial and glycocalyx measures (EndoPAT reactive hyperemia index and GlycoCheck parameters). Some hypertrophy differences were explained by BMI, hypertension, and diabetes, but the diastolic and vascular findings persisted after adjustment.
Read the abstract -
Published paper
Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates
This prospective observational study used sidestream dark-field imaging with GlycoCheck software to measure the perfused boundary region (PBR, an inverse marker of endothelial glycocalyx thickness) in the skin microcirculation of 85 term and 39 preterm newborns. Preterm infants, especially those born before 30 weeks, had lower PBR (i.e., larger glycocalyx dimensions) than term infants, and PBR rose (glycocalyx thinned) with increasing postnatal age. Extremely preterm infants reached higher PBR values by 6-7 weeks of life than moderately preterm or term babies measured at the same corrected gestational age.
Read the abstract -
Published paper
Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion
This exploratory cross-sectional study used sublingual sidestream dark field imaging (GlycoCheck) plus blood markers to compare endothelial glycocalyx status in 137 third-trimester pregnant women. Women with early-onset preeclampsia (<34 weeks) showed greater glycocalyx degradation (higher perfused boundary region) and fewer capillaries filled with red blood cells than normotensive women, women with gestational diabetes, or those with late-onset preeclampsia. Circulating heparan sulfate proteoglycans and hyaluronic acid were also elevated in early-onset preeclampsia.
Read the abstract